SPES proposal aims at transferring the approach and results achieved in the implementation of the OLDES platform into 4 new geographical contexts (Ferrara, Vienna, Brno and Kosice), focusing on new target diseases (respectively dementia, handicapped people, respiratory problems and social exclusion).
This project is implemented through the CENTRAL EUROPE Programme co-financed by the ERDF.
The objective of MAS is to develop a common communication platform and nanoelectronics circuits for health and wellness applications to support the development of flexible, robust, safe and inexpensive mobile AAL systems, to improve the quality of human life and improve the well-being of people.
Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is an important method of treatment for Parkinson’s disease. Though there is little doubt about the beneficial effects of STN DBS on motor functions, our knowledge of the neurostimulation mechanisms is still insufficient. Moreover, the STN is involved in more than just the motor circuits. Beside the pathophysiological aspects of movement control in humans, our proposed project is designed to study the STN DBS effects on visual functions and on the perception of affectively charged stimuli. Using functional magnetic resonance imaging (fMRI) we expect to observe cortical and subcortical regions influenced by STN DBS. Due to different nature of pharmacological and neurostimulation treatment we expect to detect STN DBS mechanisms different from the central effects of dopaminergic treatment. Using perioperative single-cells recording we will search for subthalamic neurons involved in the affective circuits. We expect our experiments to contribute to better understanding of mechanisms of DBS and to general knowledge of the functioning of basal ganglia in the human brain.